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Moumoujus

CYMBOPOGON NARDUS HERB OIL.

Questionable CAS 89998-15-2 / PERFUMING

Cymbopogon Nardus Herb Oil, derived from Citronella grass, is recognized for its broad spectrum of beneficial properties, including antimicrobial, anti-inflammatory, and antioxidant activities. It functions as a skin tonic, aiding in oil balance and elasticity while offering cytoprotective benefits by inhibiting cellular aging.

Summary

masking tonic antiseptic antifungal antibacterial anti-inflammatory antioxidant cytoprotective

Science

Mechanism of Action

This botanical oil acts as a skin tonic by assisting in the regulation of sebum production and enhancing skin elasticity. Its potent antiseptic, anti-fungal, anti-bacterial, and anti-inflammatory attributes contribute to skin revitalization and the reduction of redness. Furthermore, it demonstrates cytoprotective capabilities by inhibiting cellular senescence and the activity of matrix metalloproteinase-2 (MMP-2), alongside exhibiting antioxidant properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.0000244–10%
Optimal

N/A

Key findings

  1. 01 Antifungal activity against Candida species and inhibition of Candida albicans hyphae growth.
  2. 02 Minimum Inhibitory Concentration (MIC) against Staphylococcus aureus when encapsulated in liposomes.
  3. 03 Minimum Inhibitory Concentration (MIC) against various bacterial isolates and ATCC type strains.
  4. 04 Reduction of MMP-2 activity in Vero-induced Dox cells, indicative of cellular senescence inhibition.
  5. 05 Accelerated healing of ORF virus wounds in sheep.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH 5.1 – 5.1
0 7 14

Stability

A nanoemulsion incorporating Cymbopogon nardus essential oil exhibits stability at a mildly acidic pH of 5.1. As essential oils are inherently prone to oxidation, the inclusion of antioxidants and appropriate packaging is recommended to maintain stability. Formulation into nanoemulsions utilizing surfactants, such as Tween 60 and Span 60, can further enhance its stability and efficacy.

Synergies

  • Encapsulation in liposomes can enhance its antibacterial potency and stability.

Conflicts

  • Contains common fragrance allergens including geraniol, citronellal, citral, eugenol, menthol, citronellol, geranyl acetate, and linalool, which may lead to allergic reactions or skin irritation.
  • Requires dilution with carrier oils before topical application to mitigate potential skin irritation, especially for sensitive individuals.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While permitted in cosmetics within Europe and the USA, Cymbopogon Nardus Herb Oil may induce allergic reactions or skin irritation in some individuals. A skin sensitivity test is advised prior to use, and it must be diluted with carrier oils for topical application. Pregnant women and breastfeeding mothers should consult a specialist before use. The European Chemicals Agency (ECHA) reports limited evidence of dermal toxicity or allergies, while the US FDA deems it safe for specific, limited use in food. Environment Canada classifies it as a low human health priority, not expecting it to be significantly toxic or harmful. Cytotoxicity (IC50) has been observed on Vero and NIH-3T3 cell lines at concentrations greater than 0.01%.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite its promising antimicrobial, anti-inflammatory, and anti-aging benefits, Cymbopogon Nardus Herb Oil carries a significant risk of allergic reactions and skin irritation due to its high concentration of common fragrance allergens, warranting cautious formulation and use.

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