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Moumoujus

CYCLOPROPYLBIMATOPROST.

Avoid CAS 1138395-12-6 / ANTIOXIDANT

Cyclopropylbimatoprost is a synthetic prostaglandin analogue primarily recognized for its application in eyelash enhancement. It functions by activating specific receptors to prolong the anagen (growth) phase of hair follicles, contributing to increased hair density and length.

Summary

Hair Growth Stimulant

Science

Mechanism of Action

As a synthetic analogue of prostaglandin F2α (PGF2α), Cyclopropylbimatoprost operates by activating PGF (FP) and PGE (EP) receptors. This activation is understood to stimulate the hair growth cycle, specifically extending the anagen (growth) phase of hair follicles, leading to enhanced hair appearance.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The available research does not provide information regarding 'dusting' of Cyclopropylbimatoprost. Prostaglandin analogues are noted for their potential efficacy at very low concentrations, which is a different context than inactive ingredient dusting.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

An optimal pH range for stability is not specified. Based on similar prostaglandin analogues, it is recommended to store Cyclopropylbimatoprost tightly sealed, in a cool (2-8°C), dry, well-ventilated environment, away from heat and flame. Storage under inert gas is also advised due to its hygroscopic nature.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Scientific Committee on Consumer Safety (SCCS) has expressed significant concerns regarding the safety of prostaglandin analogues in cosmetic products, particularly due to their potency at very low concentrations and intended use near the eyes. The SCCS was unable to conclude on the safety of similar analogues (isopropyl cloprostenate and ethyl tafluprostamide) at proposed use concentrations, implying a broader safety concern for this class. Cyclopropylbimatoprost is currently on the Cosmetic Ingredient Review (CIR) 2023 Draft Priority List for assessment. In the US, products making eyelash growth claims with such ingredients may be regulated as drugs by the FDA.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant safety concerns raised by regulatory bodies, including potential potent effects at very low concentrations and a current lack of conclusive safety data for cosmetic applications, Cyclopropylbimatoprost is not recommended for use in precision skincare.

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