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CYCLOPENTADECENONE.

Optional CAS 35720-57-1 / PERFUMING

Cyclopentadecenone is a sophisticated macrocyclic musk utilized in precision skincare and fine fragrance for its exceptional fixative properties. It imparts a velvet-like, powdery softness to formulations while enhancing the longevity of other olfactory components on the skin's surface.

fragrance perfuming fragrance enhancer

Science

It acts as a high-substantivity fragrance agent that adheres to the skin and hair through its lipophilic nature. Beyond providing a musky olfactory profile, it functions as a 'volume booster' for other aromatic molecules, creating a more cohesive and enduring sensory experience.


Research

High confidence
Effective range 0.05–0.5%
Optimal

0.3%

Key findings

  1. 01 Research by Firmenich indicates that at concentrations between 0.05% and 0.5%, it acts as a significant fragrance enhancer, while higher levels are used to establish a distinct musky, cosmetic-soft character.

Transparency

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Because it is effective as an enhancer at very low concentrations (starting at 0.05%), it is rarely 'dusted' in the traditional sense; however, levels below 0.01% would likely yield no perceptible olfactory or fixative benefit.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Demonstrates excellent stability in alcoholic solutions and functional personal care bases; highly resistant to degradation in standard cosmetic environments.

Synergies

  • Macrocyclic musks
  • Chypre accords
  • Leather notes

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

While not specifically reviewed by the CIR, its isomer (Muscenone) has been cleared by RIFM with a high No Expected Sensitization Induction Level (NESIL) of 10,000 μg/cm2 and a Margin of Exposure > 100 for systemic toxicity.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A high-performance aromatic fixative that adds structural depth and a soft, powdery finish to the sensory profile of a product.


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