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Moumoujus

CYCLOHEXYLETHYL BUTYRATE.

Avoid CAS 63449-88-7 / FRAGRANCE

Cyclohexylethyl Butyrate is an ester primarily utilized as a fragrance compound in various personal care products. While specific clinical studies on its direct topical efficacy are absent, its potential benefits are attributed to its hydrolysis product, butyrate, a short-chain fatty acid crucial for maintaining skin health.

Summary

Science

Mechanism of Action

The proposed mechanism of action for Cyclohexylethyl Butyrate on the skin is indirect, relying on its hydrolysis into butyrate. Butyrate is known to exert anti-inflammatory effects by inhibiting cytokine and inflammatory cell production, promoting the proliferation of regulatory T cells (Tregs), and acting as a histone deacetylase inhibitor to modulate gene expression. It also contributes to skin microbiome homeostasis, offers protective effects against infection and ultraviolet radiation, and supports wound healing processes.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

ECHA classifies 1-Cyclohexylethyl butyrate (INCI: CYCLOHEXYLETHYL BUTYRATE) with GHS hazard statements H315 (Causes skin irritation) and H319 (Causes serious eye irritation), with a 94.9% notification ratio for both. This indicates a high likelihood of irritation to both skin and eyes. EWG Skin Deep assigns a 'LOW' concern for cancer, allergies & immunotoxicity, and developmental and reproductive toxicity, and it is not suspected to be persistent or bioaccumulative. No specific CIR or SCCS safety assessments were found.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite the theoretical benefits of its butyrate hydrolysis product, Cyclohexylethyl Butyrate is directly classified as a skin and eye irritant, making it unsuitable for precision skincare formulations.

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