Science
Mechanism of Action
It functions as a delivery vehicle for fragrances and other solutes; however, at the cellular level, it has been shown to stimulate the release of IL-1α, a pro-inflammatory cytokine, in human keratinocytes. At higher concentrations, it may disrupt the epidermal barrier, leading to irritation or localized tissue damage.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A 5.3 x 10-2 M concentration was found to stimulate a 10-fold increase in IL-1α in human keratinocytes, indicating high irritation potential.
- 02 In vivo rabbit studies demonstrated that high-dose dermal application (35-130 mL) caused localized ulceration, skin thickening, and systemic central nervous system toxicity.
Transparency
Dusting Analysis
Cyclohexanol is not a bioactive 'hero' ingredient; it is typically a functional additive or trace byproduct in fragrance profiles.
The Formula
Formulation
Stability
A colorless substance with a melting point of 25.93 °C. Aqueous solutions at 40 g/L maintain a pH of approximately 6.5. It is combustible and requires careful handling in formulation.
Conflicts
- Strong oxidizers
- Alkali metals
- Nitrides
- Strong reducing agents
- Carboxylic acids
- Isocyanates
- Epoxides
Safety
Safety Profile
There is currently no CIR safety report for Cyclohexanol in cosmetics. Its ability to be absorbed dermally and cause systemic effects at high doses is a notable safety concern.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cyclohexanol presents a high risk of irritation with no documented physiological benefits for the skin, making it unsuitable for precision skincare.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources