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Moumoujus

CYANOMETHYLPHENYL MENTHANE CARBOXAMIDE.

Insufficient Data CAS 852379-28-3 / ORAL CARE

CYANOMETHYLPHENYL MENTHANE CARBOXAMIDE is a potent synthetic cooling agent designed to activate temperature-sensing pathways in the skin. It elicits a distinct sensation of coolness and may modulate the skin's response to uncomfortable heat stimuli.

Summary

Cooling agent Sensory modulator

Science

Mechanism of Action

Functioning as N-(4-cyanomethylphenyl)-p-menthanecarboxamide (GIV1), this compound precisely activates TRPM8 channels, the primary thermoreceptors responsible for sensing cold. This activation extends to modulating primary and second-order trigeminal sensory neurons, generating a perceived cooling effect and diminishing the perceived intensity of noxious heat.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The FDA no longer permits the use of this and six other synthetic flavoring substances for flavoring applications. Additionally, its use in fragrance compositions is not recommended. A comprehensive safety assessment for topical skincare application by regulatory bodies like CIR or SCCS is currently unavailable, leaving potential irritancy or sensitization profiles unquantified.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While its scientific mechanism for inducing a cooling sensation is established, the critical absence of specific human skincare efficacy, comprehensive safety data, and regulatory review renders its current inclusion in precision skincare formulations unadvisable.

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