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CYANOCOBALAMIN/YEAST POLYPEPTIDE.

Valuable CAS - / SKIN CONDITIONING

This innovative complex combines Cyanocobalamin (Vitamin B12) with yeast polypeptides to deliver comprehensive skin benefits. It is precisely formulated to soothe irritation, provide protection against environmental stressors, and enhance overall skin vitality, particularly benefiting dry and sensitive skin types.

Summary

Antioxidant Skin-conditioning agent Skin protectant Anti-inflammatory/Soothing Supports skin microbiome Anti-aging Promotes skin radiance Nitric oxide scavenger Film former

Science

Mechanism of Action

Cyanocobalamin, a key component, acts as a powerful antioxidant, actively neutralizing free radicals responsible for visible signs of aging. It stimulates metabolic processes within skin cells, contributing to a reduction in skin fatigue, dullness, or grayness, thereby promoting a natural glow. The ingredient also effectively reduces skin irritation, calms sensitivity, and lessens redness, functioning as a nitric oxide scavenger and supporting a balanced skin microbiome. Yeast-derived polypeptides generally serve as skin-conditioning agents, create protective films, and act as skin protectants.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–5%
Optimal

N/A

Key findings

  1. 01 Topical cyanocobalamin concentrations from 0.5% to 5% have demonstrated efficacy in preventing or mitigating dermatological conditions such as atopic dermatitis and psoriasis. It works by counteracting irritants, especially for dry, itchy, or scaly skin, while defending against external stressors and supporting the skin's microbiome.

Transparency

Dusting Analysis

Not commonly dusted

No specific data regarding dusting potential was identified for this ingredient complex.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

Cyanocobalamin (Vitamin B12) is water-soluble but highly sensitive to degradation by light, heat, moisture, oxidizing agents, reducing agents, acids, and bases. Its stability in aqueous solutions is compromised by exposure to light and can be further accelerated by the presence of other B vitamins (e.g., Riboflavin/B2) and Vitamin C (Ascorbic acid). Formulations should therefore be protected from light and stored in cool, dry conditions.

Conflicts

  • Light
  • Heat
  • Oxidizing agents
  • Reducing agents
  • Strong acids
  • Strong bases
  • Vitamin B2 (Riboflavin)
  • Vitamin C (Ascorbic acid)
  • Cobalt sensitivity (for individuals with known allergies to cobalt, a component of cobalamin)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has a draft report for 'Yeast-derived ingredients' but lacks a specific safety assessment for 'CYANOCOBALAMIN/YEAST POLYPEPTIDE'. Cyanocobalamin, the synthetic form of Vitamin B12, is FDA-approved for treating B12 deficiencies in drug applications. Saccharomyces cerevisiae (a type of yeast) is generally recognized as safe (GRAS) by the FDA for food use up to 5%. Topical cosmetic use levels for cyanocobalamin typically range from 0.5–5%. For general yeast-derived ingredients, reported maximum use concentrations in cosmetics range up to 14.6%. Individuals with known cobalt allergies should exercise caution due to cobalt being a component of cobalamin.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

This complex of Cyanocobalamin and yeast polypeptide is a valuable ingredient for soothing sensitive and dry skin, offering notable antioxidant benefits and microbiome support, despite the current 'insufficient data' status from CIR for the combined complex.

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