Science
Mechanism of Action
As a source of copper ions, Cupric Chloride functions by supporting crucial enzymatic activities, such as those of superoxide dismutase for antioxidant protection and lysyl oxidase for collagen cross-linking. It also contributes to angiogenesis and exhibits antimicrobial action through membrane disruption and reactive oxygen species generation, targeting bacterial cells.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Aqueous solutions of Cupric Chloride are inherently acidic, typically around pH 2.0 (range 1.5 to 2.5). They may undergo slight hydrolysis if not stabilized with a small amount of acid.
Conflicts
- Potassium
- Sodium
- Hydrazine
- Nitromethane
- Aluminum
- Strong oxidizers
- Acetylene
- Sodium hypobromite
- Bases
- Bicarbonate
- Other metals (potential corrosion in presence of moisture)
- Acids (may release toxic chloride fumes)
Safety
Safety Profile
While approved by the FDA for intravenous copper supplementation, Cupric Chloride lacks specific regulation or assessment for direct topical cosmetic use by the FDA, CIR, or SCCS. The raw ingredient is classified as harmful upon ingestion or skin contact, causing skin irritation, redness, itching, and potential dermatitis. Serious eye damage, including conjunctivitis or corneal injury, is a significant risk. Copper hypersensitivity reactions have also been reported.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its role as a source of essential copper ions, Cupric Chloride is questionable for skincare due to a lack of topical efficacy data, high irritation potential, and absence of regulatory assessment for cosmetic use.
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References
Sources