CUDRANIA TRICUSPIDATA BRANCH/LEAF EXTRACT.

This extract operates via a dual-action pathway to promote skin well-being. Its antioxidant efficacy is primarily achieved by neutralizing reactive oxygen species (ROS) and activating the Nrf2/ARE signaling pathway, crucial for cellular defense. Simultaneously, it exhibits potent anti-inflammatory properties through the inhibition of pro-inflammatory cytokines, specifically IL-6 and IL-8, in human keratinocytes. Furthermore, research in mice models suggests it can modulate inflammatory responses associated with atopic dermatitis by reducing plasma levels of mTARC, histamine, and IgE. Preliminary evidence, largely from root extract studies, also indicates potential for inhibiting tyrosinase, which may contribute to skin brightening, and elastase inhibition for anti-aging benefits.