Science
Mechanism of Action
Croton gratissimus contains active compounds, primarily terpenoids and flavonoids, which are understood to confer antioxidative, anti-inflammatory, and antimicrobial benefits. Its mechanism involves free radical scavenging and the inhibition of inflammatory mediators such as nitric oxide and 15-lipoxygenase enzymes.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In vitro studies on *Croton gratissimus leaf extracts* demonstrated antioxidant and anti-inflammatory activities, showing reduced cytotoxicity to non-cancerous cells at concentrations ranging from 152.30 to 462.88 µg/mL (LC50).
- 02 An *herbal tea infusion* of Croton gratissimus exhibited significant DPPH radical scavenging activity, with an IC50 of 0.01 µg/mL, comparable to ascorbic acid. It also supported endogenous antioxidant enzyme activities (GSH, SOD, catalase) in hepatic tissues.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not evaluated CROTON GRATISSIMUS SEED EXTRACT. Neither the SCCS nor the FDA has provided a direct assessment for its cosmetic use. The broader Croton genus may contain diterpenoids known to cause skin and mucous membrane irritation. General toxicity for *Croton gratissimus* is not fully established, with some research indicating potential hepatotoxicity and genotoxicity, underscoring a need for more comprehensive safety research.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising traditional uses and in vitro antioxidant/anti-inflammatory properties in related plant parts, the lack of specific safety and efficacy data for CROTON GRATISSIMUS SEED EXTRACT in topical applications for skincare deems its inclusion as having insufficient data for precision formulation.
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References
Sources