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Moumoujus

CROTON GLABELLUS BARK OIL.

Avoid CAS 8007-06-5 / 84836-99-7 / FRAGRANCE

Croton Glabellus Bark Oil is an extract primarily valued for its aromatic qualities in fragrance and flavoring industries. While the FDA classifies 'Cascarilla Bark, Oil (Croton spp.)' including Croton glabellus, as Generally Recognized As Safe for these specific applications, related Croton species are strongly associated with potent skin irritation and pro-inflammatory responses, raising significant caution for its direct use in precision skincare formulations.

Summary

Science

Mechanism of Action

Specific mechanisms detailing beneficial cutaneous effects of Croton Glabellus Bark Oil are not extensively documented within the provided research. However, general 'Croton oil' from related species is known to induce pro-inflammatory effects and demonstrates in vitro and in vivo antibacterial and antifungal efficacy against various microorganisms. It's important to note that these pro-inflammatory properties, particularly at certain concentrations, have been leveraged in research models to elicit skin inflammation and carcinogenesis.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Conflicts

  • Components commonly found in related Croton eluteria bark oil, such as carvone and eugenol, are identified as potential sensitizers. Methyl eugenol, an animal carcinogen, also necessitates strict adherence to restricted usage limits in formulations.
  • Given the well-documented irritant properties of general Croton oil, this ingredient is incompatible with formulations intended for sensitive skin or products requiring a non-irritating profile.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Cosmetic Ingredient Review (CIR) has not provided a specific assessment for Croton Glabellus Bark Oil. Although the FDA lists 'Cascarilla Bark, Oil (Croton spp.)', which encompasses Croton glabellus, as Generally Recognized As Safe (GRAS) for use as a flavor and fragrance ingredient, general 'Croton oil' (frequently referring to Croton tiglium oil) is extensively documented as a potent skin irritant and a potential carcinogen due to the presence of phorbol esters. Related Croton eluteria bark oil may contain restricted substances like carvone and eugenol (known sensitizers) and methyl eugenol (a potential animal carcinogen), which mandate careful consideration of their concentration levels in any formulation.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to significant concerns regarding skin irritation, the presence of potentially sensitizing and carcinogenic components found in related species, and a lack of established beneficial mechanisms for skincare, Croton Glabellus Bark Oil is not recommended for precision skincare formulations.

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