Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

CRINUM ASIATICUM EXTRACT.

Insufficient Data CAS 93333-92-7 / SKIN CONDITIONING

Derived from the 'poison bulb' plant, Crinum asiaticum extract demonstrates significant biological activity relevant to skincare. It offers robust antioxidant and anti-inflammatory benefits, alongside notable antimicrobial properties, making it a versatile ingredient for various dermatological concerns.

Summary

Antioxidant Anti-inflammatory Antimicrobial Antifungal Wound Healing Support Hair Development Modulator Anti-Edematogenic

Science

Mechanism of Action

Crinum asiaticum extract exerts its beneficial effects through several distinct mechanisms. Its potent antioxidant capabilities arise from the neutralization of harmful free radicals, such as DPPH radicals. Anti-inflammatory action is achieved by inhibiting the production of key proinflammatory mediators, including nitric oxide (NO), prostaglandin E2 (PGE2), and tumor necrosis factor-alpha (TNF-α), a process attributed in part to compounds like lycorine. The extract also possesses direct antimicrobial and antifungal properties against a spectrum of Gram-positive and Gram-negative bacteria, as well as various fungal species. Furthermore, it has been shown to promote wound healing when applied topically and may influence hair development by inhibiting the TGF-b1-induced canonical pathway and 5a-reductase activity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Potent in vitro anti-inflammatory activity observed in an optimized hydrogel patch formulation.
  2. 02 Outstanding free radical scavenging capabilities demonstrated by a methanolic bulb extract.
  3. 03 Strong antibacterial action evidenced against Shigella boydii (essential oil of leaves).
  4. 04 Significant antifungal action against Candida albicans and Rhizopus sp. (essential oil of leaves).
  5. 05 Exhibited protective effects on human erythrocytes against oxidative damage (ethanolic leaf extract).
  6. 06 Demonstrated anti-edematogenic effects in carrageenan-induced paw edema (ethanolic leaf extract in animal models).
  7. 07 Reported to have wound healing abilities when applied topically.
  8. 08 May influence hair development by inhibiting the TGF-b1-induced canonical pathway and 5a-reductase activity (C. asiaticum var. japonicum extract).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Pre-extraction treatments, such as hot air drying of leaves, can significantly impact the extract's chemical composition and anti-inflammatory activity. Formulation with varying concentrations of polymers, such as HPMC, affects film properties; 2.5% HPMC typically yields moderately rough and flexible films, while 5% HPMC can result in harder, thicker, and less flexible films.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Data regarding the toxicity and clinical efficacy of Crinum asiaticum extract specifically for cosmetic applications remains sparse. While the raw plant itself is described as toxic, this characteristic does not directly translate to the safety profile of processed cosmetic extracts at regulated concentrations. No specific CIR, SCCS, or FDA review status is currently available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Crinum asiaticum extract shows compelling *in vitro* and *in vivo* evidence for antioxidant, anti-inflammatory, and antimicrobial benefits, as well as wound healing and hair growth potential; however, more dedicated human topical clinical trials and comprehensive safety assessments are needed to define its precise role and safety in advanced cosmetic formulations.

Related

Similar Ingredients

Finding similar ingredients…