Science
Mechanism of Action
When utilized as an antiseptic, specifically m-cresyl acetate, this ingredient functions by establishing an acidic microenvironment. This acidity effectively inhibits the growth and proliferation of both bacteria and fungi.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
While generally stable under recommended storage conditions, p-Cresyl acetate is noted for its particular instability, with acetates potentially forming acetic acid over time. It typically maintains color stability across most media.
Conflicts
- Strong oxidizing agents
- Strong bases
- Strong acids
- Alkalis
- Heat
- Flames
- Sparks
Safety
Safety Profile
The Research Institute for Fragrance Materials (RIFM) assessed p-cresyl acetate, finding it non-genotoxic and non-phototoxic/photoallergenic. Repeated dose and reproductive toxicity studies indicated a Margin of Exposure (MOE) exceeding 100, and skin sensitization exposure was below the Derived Sensitization Threshold (DST). However, Safety Data Sheet (SDS) information for p-Cresyl Acetate highlights it as harmful if swallowed, a cause of skin irritation, and serious eye irritation, with potential for respiratory irritation. The Scientific Committee on Consumer Safety (SCCS) has not specifically reviewed Cresyl Acetate or its isomers for cosmetic use. Under U.S. law, it does not require FDA pre-market approval for cosmetics and is recognized as a flavoring agent. Acute dermal LD50 in rabbits was reported at 2.1 g/kg. Typical concentrations in fragrance compounds range from 0.120% to 6.000%, averaging 0.900%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Given its high irritancy potential and primary use as a fragrance rather than a targeted skincare active, Cresyl Acetate's benefit-to-risk ratio for precision skincare formulations is unfavorable.
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References
Sources