Science
Mechanism of Action
This extract functions as a robust antioxidant, actively shielding keratinocytes and fibroblasts from UV-induced damage and oxidative stress. It possesses anti-inflammatory capabilities, aids in stabilizing collagen, and promotes the production of type I procollagen, thereby supporting skin elasticity and resilience. Furthermore, it demonstrates antimicrobial efficacy, particularly against streptococcal dermal infections, and has traditional applications in wound healing and managing dermatitis.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Conflicts
- Beeswax (can inhibit the release of active compounds from topical preparations)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not assessed topical Crataegus Oxyacantha Stem Extract. While no specific topical safety assessments were found, oral studies on Crataegus oxyacantha fruit and leaf extracts have demonstrated genotoxic and mutagenic effects at concentrations of 10 µg/ml or higher in cultured cells and bacteria. An aqueous extract also showed a teratogenic effect in a rat model during pregnancy when administered orally. These findings, though primarily from oral administration, necessitate caution for topical use, especially prolonged or high-dose applications, and suggest it should be avoided during pregnancy until specific topical safety data is available. An FDA warning exists regarding adulteration of Crataegus mexicana in oral supplements with cardiotoxic yellow oleander.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While offering promising mechanistic benefits for skin health, the absence of specific topical clinical efficacy data and notable oral safety concerns regarding genotoxicity and teratogenicity require a cautious approach for precision skincare applications.
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References
Sources