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Moumoujus

CORYDALIS OCHOTENSIS EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Corydalis Ochotensis Extract is a botanical ingredient broadly recognized for its skin conditioning properties. While direct clinical data for this specific species in topical applications is limited, related Corydalis extracts have shown potential in modulating cellular senescence and inflammation, suggesting a broader role in skin health.

Summary

skin conditioning potential anti-aging potential anti-inflammatory

Science

Mechanism of Action

The proposed mechanisms of action for Corydalis extracts are multifaceted. Extracts, such as from Corydalis heterocarpa, appear to exert anti-aging effects by inhibiting key cellular senescence markers like p53, p21, and caveolin-1, while simultaneously promoting autophagic flux, partly via the AMPK/mTOR pathway modulation. Furthermore, Corydalis Tuber extracts exhibit anti-inflammatory actions by modulating inflammatory mediators, cytokines, and chemokines, thereby reducing inflammatory cell infiltration and alleviating stress-related factors through the inhibition of Janus kinase-signal transducers and activators of transcription and nuclear factor kappa-light-chain-enhancer of activated B cells pathways. These therapeutic effects are generally attributed to the bioactive alkaloids present within Corydalis species.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information regarding dusting potential or prevalence was found in the research data for Corydalis Ochotensis Extract.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While a specific optimal pH range for Corydalis Ochotensis Extract stability is not documented, research on other Corydalis extracts suggests that their alkaloid components can be influenced by pH. Analytical separations of such compounds have been performed at a wide pH range, specifically pH 3.0 and pH 10.5.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

There are no direct safety assessments from bodies like CIR, SCCS, or FDA specifically for the topical application of Corydalis Ochotensis Extract. Concerns regarding the safety of some Corydalis species, particularly those containing the alkaloid tetrahydropalmatine (THP), have been primarily associated with severe liver injury and other significant side effects when ingested orally. These oral toxicity concerns do not automatically translate to topical use. Reputable industry resources, such as Paula's Choice, currently indicate this ingredient as 'Not rated' and report 'No known benefits' from a safety and efficacy standpoint.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite promising preliminary research on related Corydalis species regarding anti-aging and anti-inflammatory benefits, there is currently a lack of specific clinical efficacy and safety data for Corydalis Ochotensis Extract in topical applications to definitively assess its value.

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