Science
Mechanism of Action
This extract functions as a natural humectant by attracting moisture to the skin's surface. On a cellular level, related phytochemicals from the Cornus genus exhibit bio-activity by inhibiting NF-κB and MAPK signaling pathways, effectively downregulating pro-inflammatory cytokines like TNF-α and IL-6, while the presence of iridoid glycosides provides potent antioxidant protection and potential tyrosinase inhibition.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 A study on Cornus controversa leaf and stem extracts demonstrated a significant reduction in nitric oxide, iNOS, and COX-2 expression in macrophage models without cellular toxicity.
- 02 Research on hydrophilic Dogwood extracts in surfactant systems showed a 15% to 28% reduction in skin irritation potential compared to baseline formulations.
Transparency
Dusting Analysis
Due to the scarcity of wood-specific clinical trials and its status as a botanical extract, it is frequently used at trace percentages (below 0.1%) for marketing claims rather than physiological impact.
The Formula
Formulation
Stability
The extract is generally stable in aqueous solutions; however, the source plant's preference for slightly acidic environments suggests optimal stability in standard skincare pH ranges.
Synergies
- Glycerin
- Betaine
- Antioxidants
Safety
Safety Profile
While formal CIR assessments are pending, current data on related Cornus species suggests a very high safety profile and low irritation potential.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A promising botanical humectant with notable anti-irritant potential, though more wood-specific clinical data is required for definitive efficacy.
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References
Sources