Science
Mechanism of Action
This extract functions by actively scavenging free radicals, thereby protecting human keratinocytes from oxidative damage. Its mechanism involves elevating intracellular glutathione levels, enhancing the activity of key oxidative defense enzymes like superoxide dismutase and catalase, and upregulating the expression of activated Nrf2. Beyond its robust antioxidant capabilities, the extract may also support collagen synthesis, facilitate efficient wound repair, assist in regulating sebum production, and contribute to mitigating hyperpigmentation and signs of premature aging.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Limited direct clinical studies on Coriandrum Sativum Callus Extract, specifically detailing effective topical concentrations, are available.
- 02 In vitro analyses of general Coriandrum sativum extracts (non-callus specific) have demonstrated antioxidant activity, exhibiting an IC50 of 31.98 µg/mL by inhibiting DPPH radicals.
- 03 Coriander polyphenols, isolated from Coriandrum sativum L., displayed potent in vitro antioxidant properties, with DPPH IC50 values of 73.43 µg/mL and ABTS IC50 values of 82.15 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract demonstrates stability under typical storage conditions, necessitating protection from direct sunlight and excessive heat. Formulators commonly utilize water/glycerine as a solvent and incorporate preservatives such as Potassium Sorbate, Sodium Benzoate, and Citric Acid, indicating favorable compatibility within neutral to slightly acidic pH ranges. Should a general Coriandrum sativum extract induce mild irritation, integration with soothing compounds is recommended.
Safety
Safety Profile
No direct Cosmetic Ingredient Review (CIR) safety assessment specifically for 'Coriandrum Sativum Callus Extract' has been conducted. While the FDA generally recognizes Coriandrum sativum as safe (GRAS) for food use, and animal studies suggest low acute oral toxicity for coriander seed extract (LD₅₀ >5,000 mg/kg), concerns exist for topical applications. A clinical trial involving a general Coriandrum sativum extract cream for diaper dermatitis reported mild irritation in 27% of infant participants. Furthermore, a study on a non-callus specific aqueous C. sativum extract, at high concentrations, revealed mutagenicity, reduced human cell survival, altered cell cycles, and induced severe embryonic malformations. Given these findings, particularly the observed potential for developmental toxicity from a non-callus specific extract, its use during pregnancy is explicitly not recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While *Coriandrum Sativum Callus Extract* presents promising *in vitro* antioxidant activity and a broad spectrum of potential skin benefits, direct clinical efficacy data specifically for the callus extract form remains limited. Additionally, reported instances of topical irritation and severe developmental concerns associated with non-callus specific extracts necessitate a highly cautious approach to its inclusion in precision skincare formulations.
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References
Sources