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CORDYCEPS CICADAE MYCELIUM EXTRACT.

Valuable / ANTIOXIDANT, BLEACHING, SKIN CONDITIONING, SKIN PROTECTING

Cordyceps Cicadae Mycelium Extract is a sophisticated botanical ingredient recognized for its profound hydrating, antioxidant, and anti-inflammatory properties. It actively enhances the skin's natural ability to retain moisture while offering comprehensive protection against environmental stressors and supporting cellular health for a more resilient complexion.

Summary

Moisturizing Anti-aging Antioxidant Anti-inflammatory Skin Conditioning Skin Protecting Hydrator

Science

Mechanism of Action

This extract operates through several key pathways to promote skin vitality. It directly stimulates hyaluronan (HA) synthesis in human skin fibroblasts by upregulating HA synthase 2 (HAS2) and concurrently downregulating matrix metallopeptidase 12 (MMP12), leading to enhanced skin hydration. Furthermore, it exhibits potent antioxidant capabilities by effectively neutralizing free radicals such as ABTS and DPPH. Its anti-inflammatory action is evidenced by reducing inflammatory mediators like COX-2, Prostaglandin E2 (PGE2), IL-1β, and TNF-α, alongside inhibiting the NF-κB signaling pathway. The extract also boosts cell survival and augments the activity of crucial antioxidant enzymes like GSH-Px and SOD, providing protective benefits and potentially mitigating UVB-induced damage.

Research

Clinical Evidence

Medium confidence
Effective range 0.005–0.01%
Optimal

0.01%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While the fermentation process for mycelium growth can tolerate a broad pH range of 2 to 8 (with a preferred range of 4-7), specific optimal pH parameters for the stability of the final extract within cosmetic formulations are not currently documented.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.01%
Sensitization risk Low

Although not yet reviewed by the Cosmetic Ingredient Review (CIR), in vitro studies on human skin fibroblasts indicated no cytotoxicity at concentrations up to 0.01%, which aligns with the highest efficacy concentration. Furthermore, human clinical trials involving oral administration of HEA-enriched Cordyceps cicadae mycelia (1.05 g daily for 3 months) reported no significant adverse effects on vital organ functions or blood parameters, suggesting a favorable safety profile.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cordyceps Cicadae Mycelium Extract is a valuable, multi-functional ingredient demonstrating robust in-vitro efficacy in enhancing skin hydration, providing antioxidant and anti-inflammatory benefits, and supporting comprehensive skin health.

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