Science
Mechanism of Action
This extract functions primarily through its high concentration of phenolic compounds, including ferulic, cinnamic, and p-coumaric acids, which neutralize reactive oxygen species (ROS) to prevent oxidative damage. Additionally, it inhibits pro-inflammatory signaling molecules such as IL-6 and TNF-alpha, while its humectant properties improve stratum corneum hydration and its antiseptic nature supports a balanced skin microbiome.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro testing demonstrated an 82.02% inhibition of free radical activity at a concentration of 80 µL/mL.
- 02 Research indicates significant anti-inflammatory potential at 50 µg/mL through the downregulation of mRNA levels for COX-2 and iNOS.
- 03 Essential oils from the leaf (EOCA) showed powerful antioxidant effects at an IC50 of 30 µg/mL for DPPH scavenging.
Transparency
Dusting Analysis
Because it is often marketed for its traditional 'wound healing' and 'antiseptic' reputation, it is frequently included at very low percentages (under 0.1%) for label claims rather than therapeutic efficacy. To achieve the documented 80%+ antioxidant inhibition seen in studies, higher concentrations are required.
The Formula
Formulation
Stability
The extract contains ferulic and cinnamic acids which may be sensitive to UV light and high temperatures; however, specific pH stability ranges for the whole cell extract are not yet standardized.
Synergies
- Vitamin C
- Vitamin E
- Hyaluronic Acid
Safety
Safety Profile
While oral ingestion of large quantities is associated with gastrointestinal and renal irritation, topical application of high-molecular-weight extracts has demonstrated low toxicity to human cells.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A promising multifunctional botanical that bridges the gap between traditional wound healing and modern antioxidant protection.
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References
Sources