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Moumoujus

CONNARUS RUBER STEM EXTRACT.

Insufficient Data / SKIN CONDITIONING

Connarus Ruber Stem Extract is a botanical ingredient derived from the Connarus ruber plant, recognized for its potent anti-glycation properties. It actively works to inhibit the formation of Advanced Glycation End-products (AGEs) and provides cellular protection against damage from glycation intermediates and oxidative stress.

Summary

Anti-glycation Antioxidant Skin conditioning Cytoprotective

Science

Mechanism of Action

Connarus Ruber Stem Extract functions by significantly inhibiting the glycation of collagen, a key process in skin aging, and preventing the formation of harmful Advanced Glycation End-products (AGEs). Its active components, notably epicatechin and procyanidin A2, contribute to attenuating cytotoxicity induced by glycation intermediates like methylglyoxal (MG) and offer protection against oxidative damage, including glycoxidation and reactive oxygen species (ROS).

Research

Clinical Evidence

Medium confidence
Effective range 0.03–0.25%
Optimal

N/A

Key findings

  1. 01 Clinical studies demonstrate that Connarus ruber extract, at concentrations ranging from 0.03% to 0.25%, dose-dependently inhibits collagen glycation induced by fructose and glyceraldehyde.
  2. 02 Further research indicates its ability to attenuate cytotoxicity caused by glycation intermediates like methylglyoxal (MG) and to protect dental pulp stem cells from glyceraldehyde-induced damage.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that Connarus Ruber Stem Extract is commonly 'dusted' or used at ineffective concentrations in formulations. Further research is needed to establish typical usage percentages in cosmetic products.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract is typically prepared using water extraction at 80°C for 30 minutes and should be stored at 4°C. The optimal pH range for stability in finished cosmetic formulations has not been specified.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not yet reviewed Connarus Ruber Stem Extract. It is considered a relatively new ingredient with limited public safety data. Paula's Choice lists it as 'not rated' and without 'known benefits' (likely due to insufficient public research for skin application), highlighting the need for more comprehensive safety assessments.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Connarus Ruber Stem Extract shows promising in vitro anti-glycation and cytoprotective effects; however, comprehensive data on its safety for topical human use and optimal formulation parameters is currently insufficient for a definitive recommendation.

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