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Moumoujus

CONIUM MACULATUM ROOT EXTRACT.

Avoid CAS 85116-75-2 / SKIN CONDITIONING

Conium Maculatum Root Extract is derived from the highly toxic Poison Hemlock plant, distinguished by its concentration of lethal piperidine alkaloids such as coniine. Historically recognized in homeopathic contexts, its potent toxicity, including documented fatal ingestions and phototoxic dermal reactions, precludes its safe use in precision skincare formulations.

Summary

masking

Science

Mechanism of Action

The primary mechanism of Conium Maculatum's activity stems from piperidine alkaloids like coniine, which can act as an anti-spasmodic by blocking nicotine receptors in muscle tissue. While low concentrations administered internally have demonstrated antioxidant properties in rat studies and the root contains beneficial steroids, contact with the skin can provoke severe phototoxic responses, resulting in rashes and blisters upon sun exposure.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Conium maculatum Root Extract is not reported for use in cosmetics and its extreme toxicity makes it unsuitable for topical application, negating any dusting concerns in this context.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability in cosmetic formulations was identified. Coniine, a key toxic component, is described as a strongly alkaline oil and is very soluble in weak acids, which it neutralizes, suggesting potential pH sensitivity.

Conflicts

  • Sunlight exposure (due to phototoxicity potential, causing rashes and persistent blisters on bare skin)
  • Any cosmetic formulation intended for safe topical application due to the plant's extreme toxicity

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Pregnancy
Caution
Sensitization risk High

The Cosmetic Ingredient Review (CIR) lists Conium maculatum Root Extract as having 'No Reported Uses' in cosmetics, thus it has not been reviewed for safety. The plant is extremely toxic; all parts, especially seeds and roots, contain toxic piperidine alkaloids. Ingestion of as little as 0.1 gram of coniine can be fatal for an adult. The FDA has not evaluated the safety or efficacy of homeopathic products containing this ingredient. Its inclusion in any cosmetic formulation is strongly discouraged due to extreme toxicity and severe phototoxic potential.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Conium maculatum Root Extract presents severe toxicity risks, including fatal ingestion and phototoxic skin reactions, rendering it entirely unsuitable and unsafe for any cosmetic application.

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