Science
Mechanism of Action
This extract primarily exerts its anti-inflammatory effects by modulating the nuclear factor-κB (NF-κB) pathway. This action helps to significantly decrease the production of key pro-inflammatory mediators, including nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Its robust antioxidant activity stems from its composition of beneficial phytochemicals such as glucoluteolin, orientin, isoorientin, and isoquercitrin. Additionally, the extract acts as a humectant, aiding in moisture retention, and provides general skin-protecting and conditioning attributes.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract's active components demonstrate water solubility, consistent with its preparation using aqueous or hydroalcoholic solvents. While precise pH stability data for Commelina communis extract is not available, its key flavonoid constituents are generally known to maintain optimal stability within a pH range of 5 to 7 in other plant extracts.
Safety
Safety Profile
No specific safety assessments have been conducted by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS), and its FDA status is currently unknown. In vitro research on murine macrophages indicated a high safety profile, showing cell viability exceeding 99% at concentrations up to 1.5 mg/mL, suggesting low cytotoxicity in that model.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While promising in vitro for its anti-inflammatory and antioxidant properties, the lack of human clinical data and comprehensive safety assessments warrants further research before widespread application.
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References
Sources