Science
Mechanism of Action
Cloflucarban acts as an antibacterial agent by disrupting bacterial cell membrane synthesis. It specifically inhibits the activity of enoyl-(acyl-carrier protein) (ACP) reductase, an enzyme critical for bacterial growth, thereby leading to the inhibition of bacterial proliferation. Its primary efficacy is directed against gram-positive bacteria.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 N,N′-diarylureas, including cloflucarban, demonstrated high in vitro activity against wild-type S. mutans CECT 479 (ATCC 25175) with a minimum inhibitory concentration 50% (MIC50) value at 0.5 µg/mL.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
In 2016, the U.S. Food and Drug Administration (FDA) banned cloflucarban for use in over-the-counter (OTC) consumer antiseptic wash products. The FDA concluded that it was not generally recognized as safe and effective (GRAS/GRAE) for these uses, citing a lack of evidence that it is more effective than plain soap and water, and expressing concerns about potential long-term harm. Its use in such consumer antiseptic washes is therefore prohibited. Cloflucarban has not been specifically reviewed by the European Commission's Scientific Committee on Consumer Safety (SCCS).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its prohibited status by the U.S. FDA for lack of proven safety and efficacy in consumer antiseptic washes, coupled with concerns regarding potential long-term harm, cloflucarban is not suitable for inclusion in precision skincare formulations.
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References
Sources