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CLERODENDRON TRICHOTOMUM STEM EXTRACT.

Valuable CAS - / SKIN CONDITIONING

A versatile botanical bioactive derived from the Harlequin Glorybower, engineered to defend against environmental photo-aging while regulating lipid production. This multi-pathway extract simultaneously targets melanin synthesis and enzymatic collagen degradation to maintain a balanced, youthful complexion.

Tyrosinase Inhibitor Antioxidant Anti-inflammatory MMP Inhibitor Sebum Regulator

Science

This extract functions through three primary pathways: it inhibits tyrosinase activity to reduce hyperpigmentation and melasma; it suppresses MMP-1 and MMP-9 enzymes via MAPK signaling to prevent UV-induced collagen breakdown; and it modulates lipoxygenase activity to decrease excess sebum production. Additionally, it acts as a potent antioxidant, neutralizing reactive oxygen species (ROS) to protect skin cells from oxidative stress.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Commonly dusted

Due to its broad-spectrum claims and the lack of standardized clinical dosage data, this botanical is frequently used at 'label claim' concentrations rather than biologically active levels in mass-market formulations.


The Formula

Solubility
Both
Optimal pH 5.5 – 6
0 7 14

Stability

The extract demonstrates versatility across aqueous, glycolic, and oil-based systems. Stability data suggests maintaining a slightly acidic environment (pH 5.6–5.9) consistent with biological culture requirements.

Synergies

  • Broad-spectrum UV filters
  • Niacinamide
  • Vitamin C

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

While systemic toxicity in animal models is extremely low (LD50 of 20.6 g/kg), specific longitudinal dermatological safety studies for topical application are currently limited.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

A high-potential multifunctional botanical that bridges the gap between sebum control and advanced photo-aging protection, though it requires more clinical data to establish definitive dosage standards.


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