Science
Mechanism of Action
This extract exerts its dermatological effects through multiple mechanisms. It exhibits anti-inflammatory properties, potentially by downregulating TNF-α, thereby reducing cellular inflammatory responses. As a rich source of phenolic compounds, flavonoids, and terpenoids, it provides robust antioxidant defense by scavenging free radicals. Additionally, Cleome Spinosa Flower Extract demonstrates antimicrobial activity against various bacteria and fungi, and has been associated with skin brightening and overall epidermal protection.
Research
Clinical Evidence
Medium confidence7%
Key findings
- 01 Cleome spinosa extract is recognized for its role in promoting hair follicle growth and acting as an antinociceptive and anti-inflammatory agent. Its volatile oil displays mild antimicrobial efficacy, including significant inhibitory action against Streptococcus pyogenes Group A.
- 02 A 7% gel formulation of *Cleome viscosa*, a related species, exhibited notable topical anti-inflammatory effects in studies, comparable to those of a standard diclofenac gel, demonstrating a dose-dependent response.
- 03 A cosmetic composition incorporating Cleome spinosa extract has been patented for its pronounced effects in skin whitening, antioxidation, and comprehensive skin protection.
Transparency
Dusting Analysis
No data suggests that Cleome Spinosa Flower Extract poses a dusting concern during handling or formulation processes.
The Formula
Formulation
Stability
Extraction methods indicate solubility in both aqueous-alcoholic solutions (e.g., 30% alcohol v/v) and various organic solvents such as methanol, ethyl acetate, and dichloromethane, pointing to a diverse chemical profile. Hot water extraction also supports the presence of water-soluble components. The existence of volatile oil components suggests lipid solubility, while the flavonoid content may contribute to enhanced stability in mildly acidic environments through chelation.
Safety
Safety Profile
Cleome Spinosa Flower Extract has not undergone specific review by the CIR or SCCS. While general handling of cleome plants is often considered safe, a publication noted 'Dermatitis as occupational disease, caused by "Kleopatra-Nadel" (Cleome spinosa),' suggesting a potential for irritancy or sensitization in certain individuals or contexts. Conversely, animal studies involving extracts from a related species, *Cleome viscosa*, at 1% and 2.5% (w/w) in hydrogel, showed no symptoms of skin irritation or inflammation. Acute oral toxicity tests for *Cleome arabica* extract in rats indicated no toxicity up to 2000 mg/kg. This suggests that the safety profile may be concentration-dependent and influenced by formulation, with specific dermal toxicity for *C. spinosa* not fully elucidated.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cleome Spinosa Flower Extract presents valuable potential for anti-inflammatory, antioxidant, and skin brightening applications within skincare, although further direct human clinical efficacy and comprehensive safety data are required for definitive assessment.
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