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Moumoujus

CLEOME GYNANDRA LEAF EXTRACT.

Valuable / ANTI-SEBUM

A multifunctional botanical powerhouse that excels in managing oil-prone and reactive complexions by harmonizing the skin's natural microbiome. This precision extract provides a comprehensive approach to skin health, combining potent antioxidant defense with advanced sebum-regulating properties.

Summary

antioxidant sebum regulator microbiome balancer anti-inflammatory collagen protector

Science

Mechanism of Action

This extract operates through a multi-pathway approach: it neutralizes reactive oxygen species to prevent lipid peroxidation while simultaneously inhibiting matrix metalloproteinases (MMPs) to protect the structural integrity of collagen and elastin. On the surface, it rebalances the skin microbiome by selectively targeting pathogenic bacteria like C. acnes and regulates both the volume and chemical composition of sebum to prevent hyperseborrhea and inflammatory flare-ups.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–3%
Optimal

3%

Key findings

  1. 01 Human cumulative irritation assessments established a non-irritating profile with a Mean Cumulative Irritation Index of 0.046.
  2. 02 In vitro testing on murine macrophage lines demonstrated over 90% cell viability at concentrations up to 2 mg/mL, indicating excellent biocompatibility.
  3. 03 Clinical recommendations suggest a 3% concentration to achieve full spectrum benefits across anti-inflammatory, UV defense, and sebum regulation parameters.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

While many formulas include botanical extracts at trace amounts (<0.1%) for marketing purposes, Cleome Gynandra requires a concentration of at least 0.5% to 1% to begin exerting its microbiome-balancing and anti-inflammatory effects, with 3% being the target for clinical results.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Highly stable when stored between 25-40°C; however, to maintain potency, avoid sustained heat exposure above 40°C during the mixing process and never exceed 80°C.

Synergies

  • Niacinamide
  • Salicylic Acid
  • Hyaluronic Acid

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Classified as non-irritating in human clinical assessments. While further large-scale human trials are beneficial, current data suggests a high safety margin for topical application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An exceptional ingredient for precision sebum control and microbiome maintenance that offers significant protective benefits for acne-prone and sensitive skin types.

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