Science
Mechanism of Action
Functions by inhibiting NF-κB signaling pathways to suppress pro-inflammatory cytokines while simultaneously activating PPARbeta/delta receptors. This dual action promotes keratinocyte migration and proliferation, accelerating wound healing and cellular regeneration while providing antioxidant defense.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies demonstrate high NF-κB inhibition at 50 µg/ml and PPARbeta/delta activation at 10 µg/ml.
- 02 Crude extracts showed antimycotic activity against pathogenic yeasts at concentrations as low as 1.4 to 12.3 µg/ml.
- 03 In vivo animal models showed dose-dependent anti-inflammatory effects using Vitalboside at 75-150 mg/kg.
Transparency
Dusting Analysis
Due to a lack of standardized cosmetic dosage guidelines, this extract is frequently included in formulations at concentrations below 0.1% for marketing purposes rather than therapeutic effect.
The Formula
Formulation
Stability
Ethanol and acetone extracts show high stability in bioactivity; should be protected from extreme heat to preserve flavonoid integrity.
Synergies
- Panthenol
- Madecassoside
- Ceramides
Safety
Safety Profile
While generally safe in regulated dilutions, the Clematis genus contains protoanemonin which can be irritating; however, this is typically neutralized during professional extraction.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-potential botanical for barrier repair and inflammation control, though more human clinical data is required to establish optimal topical percentages.
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References
Sources