Science
Mechanism of Action
This extract is believed to exert antioxidant effects through the presence of beneficial compounds such as triterpenoid saponins and flavonoids, commonly found in Clematis species. An in vitro study on rat neuronal cells indicates that an ethanolic extract of Clematis terniflora can significantly reduce apoptotic cell death and mitochondrial damage by activating AKT and ERK1/2 pathways, suggesting a cellular protective mechanism that may translate to skin health.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 An ethanolic extract of Clematis terniflora (300-500 μg/ml) significantly reduced corticosterone-induced apoptotic cell death and mitochondrial damage in rat pheochromocytoma (PC12) cells, demonstrating neuroprotective effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The extract's stability and aesthetic impact in formulations may present challenges, though specific details regarding these limitations are not fully elucidated. Water solubility is inferred given common extraction methods and the nature of its constituents like flavonol glycosides.
Safety
Safety Profile
While the fresh Clematis plant contains protoanemonin, which can cause severe skin irritation, the processed flower extract for cosmetic use is generally considered non-irritating. However, specific regulatory statuses (CIR, SCCS, FDA) for the extract in cosmetics are not readily available.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Clematis Terniflora Flower Extract shows promise as an antioxidant with cellular protective properties, though further direct clinical studies on human skin are needed to fully establish its efficacy in topical applications.
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References
Sources