Science
Mechanism of Action
This extract demonstrates significant anti-inflammatory activity by precisely inhibiting crucial mediators such as nitric oxide, cyclooxygenase-2, tumor necrosis factor-α, interleukin-6, and interleukin-1β. Its action primarily involves suppressing the activation of nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways within macrophages. The diverse array of bioactive compounds, including triterpene saponins, flavonoids, and phenolic glycosides, are believed to underpin its anti-inflammatory and prospective antioxidant capabilities.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In *in vitro* studies using corticosterone-induced rat pheochromocytoma (PC12) cells, concentrations of 0.03% and 0.05% of Clematis terniflora extract significantly reduced apoptotic cell death and mitochondrial damage, suggesting potential neuroprotective effects.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) and Scientific Committee on Consumer Safety (SCCS) have not evaluated Clematis terniflora extract for cosmetic use. The raw plant is known to contain protoanemonin, a compound that can induce contact dermatitis, redness, and a burning sensation; however, this toxicity is reported to be reduced by heat or drying. While some oral acute toxicity studies on water and 70% ethanol extracts showed no issues at 0.1 g/kg body weight, and an extract from a different *Clematis* species (C. cirrhosa) demonstrated low acute toxicity (LD50 > 5000 mg/kg), specific safety assessments for topical cosmetic applications are currently absent.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising *in vitro* anti-inflammatory and neuroprotective effects, the absence of specific topical cosmetic safety data and human clinical trials renders its use questionable for precision skincare formulations at this time.
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References
Sources