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Moumoujus

CLEMATIS CHINENSIS ROOT EXTRACT.

Insufficient Data / SKIN CONDITIONING

Clematis Chinensis Root Extract, derived from the root of the Clematis chinensis plant, is a botanical ingredient rich in active compounds such as triterpenoid saponins, alkaloids, and flavonoids. It is recognized for its potent anti-inflammatory and antioxidant properties, traditionally employed to soothe skin eruptions and contribute to skin conditioning.

Summary

Anti-inflammatory Antioxidant Skin Conditioning

Science

Mechanism of Action

This extract exerts its anti-inflammatory effects by modulating key cellular pathways, specifically inhibiting the NF-κB signaling pathway. It also reduces pro-inflammatory cytokines like TNF-α and suppresses the expression of COX-2, an enzyme central to inflammatory responses, thereby offering a multifaceted approach to calming skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro analyses demonstrated that a chloroform extract of Clematis chinensis achieved a 76.8% anti-inflammatory inhibition at a concentration of 10 µg/mL.
  2. 02 Further in vitro studies identified twelve isolated compounds, exhibiting significant inhibitory activity against TNF-α, with inhibition ratios ranging from 47.87% to 94.70% at a dose of 10 μM. Specific compounds 7 and 8 also notably decreased the activation of the NF-κB signaling pathway.
  3. 03 Pre-clinical in vivo studies on rats with collagen-induced arthritis, utilizing oral doses of 8, 16, and 32 mg/kg of AR-6 (a triterpene saponin from Clematis chinensis), showed significant improvements in paw swelling, histopathological changes, and a reduction in pro-inflammatory cytokines TNF-α and IL-1β, alongside inhibited NF-κB p65 subunits and COX-2 expression.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not conducted an assessment for Clematis Chinensis Root Extract. While traditional sources and some toxicity studies on related Clematis species highlight potential irritant and toxic effects upon oral ingestion, these findings do not directly translate to topical cosmetic application. When properly formulated, it has been noted as generally non-irritating, yet its historical classification as a mildly toxic herb suggests caution, particularly if not prepared correctly.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Clematis Chinensis Root Extract demonstrates promising in vitro anti-inflammatory and antioxidant activities, yet its overall rating is 'insufficient-data' due to a lack of comprehensive human topical efficacy studies and formal safety assessments for cosmetic use.

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