Science
Mechanism of Action
This extract operates through a dual-pathway defense system: it inhibits the aryl hydrocarbon receptor (AhR) signaling to prevent damage from pollutants like Benzo[a]pyrene and simultaneously activates the Nrf2-mediated antioxidant response. By suppressing Src phosphorylation and the production of pro-inflammatory cytokines, it effectively reduces reactive oxygen species (ROS) and cellular inflammation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies demonstrate significant protection of human keratinocytes against B[a]P-induced nuclear translocation of AhR and subsequent oxidative damage.
Transparency
Dusting Analysis
As a specialized botanical with limited clinical dose-response data, it is often included at negligible levels (<0.1%) for marketing claims rather than functional anti-pollution efficacy.
The Formula
Formulation
Stability
The extract is sensitive to environmental factors; proper heat processing or drying is required during manufacture to eliminate protoanemonin, a naturally occurring irritant.
Synergies
- Vitamin C
- Ferulic Acid
- Niacinamide
Safety
Safety Profile
Raw Clematis contains protoanemonin, which can cause blistering. While processed extracts used in skincare are generally safe, individuals with hypersensitive skin should patch test due to the risk of contact dermatitis associated with the genus.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An emerging botanical powerhouse for urban defense, though precision in sourcing and processing is critical for safety.
Related
Similar Ingredients
Finding similar ingredients…