Science
Mechanism of Action
This extract operates primarily through antioxidant action, stabilizing intracellular glutathione (GSH) to counteract oxidative stress, such as that induced by hydrogen peroxide. Its phenolic compounds contribute significantly to this protective capacity. Furthermore, specific compounds like wampetin provide anti-inflammatory benefits by inhibiting superoxide anion generation. It also promotes skin health through cytoprotection, enhancing human gingival fibroblast cell proliferation and safeguarding them from environmental stressors. Essential oils within the extract demonstrate antifungal activity.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 In vitro studies on human gingival fibroblast (HGF) cells demonstrated robust protection against hydrogen peroxide-induced cytotoxicity. A concentration of 0.05% yielded 98% cell recovery, while 0.5% provided 95% cell recovery.
- 02 At 0.5%, the extract also enhanced human gingival fibroblast cell proliferation and stabilized intracellular glutathione levels, maintaining normal cell morphology and actin staining despite oxidative challenges.
Transparency
Dusting Analysis
Insufficient data from human in-vivo studies to determine dusting practices or thresholds.
The Formula
Formulation
Safety
Safety Profile
While in vitro studies on human gingival fibroblast cells indicated no cytotoxicity at concentrations up to 0.5% (5000 μg/mL) after 24 hours, Clausena lansium Leaf Extract has not yet undergone official safety review by regulatory bodies such as CIR, SCCS, or FDA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Clausena lansium Leaf Extract is a valuable, multi-functional botanical extract exhibiting strong antioxidant, anti-inflammatory, and cytoprotective properties for comprehensive skin support, though its full potential and safety profile would benefit from further in-vivo human studies and regulatory assessment.
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References
Sources