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Moumoujus

CITRUS TAMURANA FRUIT EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Citrus Tamurana Fruit Extract is a multi-functional botanical ingredient recognized for its skin-conditioning and humectant properties. In scientific models, it has demonstrated the ability to promote skin cell proliferation and migration, suggesting potential benefits for skin regeneration and repair.

Summary

Skin-conditioning Humectant Cell Proliferation Wound Healing Support (In Vitro)

Science

Mechanism of Action

This extract stimulates skin fibroblast proliferation and migration by enhancing the expression of key signaling proteins (Rac-1, Rho-A, and Cdc-42) and increasing Cyclin-dependent kinase (Cdk-1 and -2) gene expression. Additionally, it functions as a humectant, attracting and retaining moisture to improve skin hydration.

Research

Clinical Evidence

Low confidence
Effective range 0.1–0.75%
Optimal

N/A

Key findings

  1. 01 An in vitro study demonstrated that Citrus tamurana extract, at concentrations ranging from 0.1 to 0.75 mg/mL, linearly and time-dependently promoted skin fibroblast proliferation and accelerated cellular migration crucial for wound healing. Specifically, a concentration of 0.75 mg/mL significantly advanced cell cycle progression (G2/M phases). However, concentrations exceeding 1.0 mg/mL were found to inhibit proliferation.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for stability has been identified. The extract contains both oil-soluble volatile compounds (e.g., limonene, gamma-terpinene, myrcene) and water-soluble fruit components. The composition and stability of the volatile fraction can be influenced by factors such as harvesting time, fruit freshness, and size.

Conflicts

  • Formulations exceeding 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP) in leave-on products
  • High concentrations of botanical constituents like limonene, citral, other monoterpenes, and furocoumarins that could cause sensitization or adverse effects
  • Other photosensitizing ingredients that could exacerbate potential phototoxicity from furocoumarins

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Moderate

The CIR Expert Panel concludes citrus fruit-derived ingredients, including Citrus Tamurana Fruit Extract, are safe for cosmetic use when formulated to be non-sensitizing and non-irritating. For leave-on products, formulations must strictly adhere to a maximum of 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP). Formulators must also monitor other botanical constituents such as limonene, citral, and furocoumarins to prevent sensitization or adverse effects. The U.S. FDA recognizes Citrus fruits as Generally Recognized As Safe (GRAS) for direct food use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Citrus Tamurana Fruit Extract offers valuable humectant and skin-conditioning benefits, with promising in vitro evidence for promoting skin repair, provided it is carefully formulated to adhere to safety limits for photosensitizing compounds like 5-MOP.

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