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Moumoujus

CITRUS TAMURANA FLOWER EXTRACT.

Valuable CAS - / SKIN CONDITIONING

Citrus Tamurana Flower Extract is a botanical active exhibiting promising in vitro capabilities for skin regeneration. It actively stimulates the proliferation and migration of skin fibroblasts, essential cells for maintaining skin structure and facilitating repair processes. This extract can serve as a valuable component in formulations designed for advanced skin renewal and repair.

Summary

Skin conditioning agent Supports skin renewal Promotes fibroblast proliferation Supports wound healing

Science

Mechanism of Action

The extract operates by promoting the proliferation and migration of TIG-119 skin fibroblasts. It accelerates the G2/M phases of the cell cycle, a critical stage in cellular division, indicating enhanced regenerative potential. This mechanism involves the overexpression of key signaling proteins (Rac-1, Rho-A, Cdc-42 mRNA and proteins) and increased gene expression of Cyclin-dependent kinases (Cdk-1 and Cdk-2), collectively supporting the skin's natural wound healing properties.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.075%
Optimal

0.075%

Key findings

  1. 01 In vitro studies on TIG-119 skin fibroblasts demonstrated a linear and time-dependent increase in cell proliferation across concentrations from 0.01% to 0.075%.
  2. 02 At a concentration of 0.075%, the extract significantly accelerated the G2/M phases of the cell cycle, indicating enhanced cellular repair and regeneration.

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
above 0.1%

While lower concentrations (0.01% to 0.075%) promote fibroblast proliferation, concentrations exceeding 0.1% were observed to inhibit this activity. This indicates a critical upper limit for effective formulation, where precision is paramount to harness its beneficial effects.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Constituents of citrus essential oils, which may be present in the extract, are generally sensitive to heat. Changes in terpene and aldehyde profiles have been noted at storage temperatures of 20°C and above, suggesting potential thermal instability for some components within the extract. Careful temperature control during formulation and storage is advisable.

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Moderate

The CIR Expert Panel considers Citrus Tamurana Flower Extract safe when formulated to be non-irritating and non-sensitizing. A critical restriction for leave-on products is that the 5-methoxypsoralen (5-MOP) content must not exceed 0.0015% (15 ppm) due to phototoxicity concerns. EU regulations further mandate furocoumarin content to be below 1 mg/kg in sun-protection and bronzing products. Adherence to these limits is essential to mitigate potential sensitization and phototoxic reactions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Citrus Tamurana Flower Extract offers valuable in vitro potential for skin renewal and repair by promoting fibroblast proliferation, provided that specific phototoxic constituents are meticulously controlled within established safety limits for optimal use.

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