Science
Mechanism of Action
This ingredient functions through various pathways: its robust antioxidant properties, primarily attributed to flavonoids and other bioactive compounds, help mitigate oxidative stress and protect against free radical damage. Additionally, it exhibits anti-inflammatory effects, thought to be mediated by compounds such as cucurbitacin and polyphenols. Studies also indicate antimicrobial and antibacterial activities, and traditional applications include promoting skin healing and potentially contributing to skin tone evenness.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 systemic therapeutic effects through dermal absorption
- 02 strong antioxidant activity
- 03 dose-dependent antioxidant activity
- 04 antiproliferative activity against cancer cells and non-toxic to healthy fibroblasts
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While in vitro studies indicated non-toxicity of seed extract to healthy human dermal fibroblasts, definitive topical safety assessments by CIR or SCCS are currently unavailable. It is important to note that oral consumption exceeding 400 mg/kg has been linked to digestive and liver disorders in humans, and animal studies reported severe organ damage at 100 mg/kg of pulp extract. These oral toxicity findings underscore a need for caution, as dermal absorption, though demonstrated, differs significantly from oral intake. INCI Beauty lists no known penalties for this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in vitro antioxidant and anti-inflammatory data and demonstrated dermal absorption, insufficient human topical clinical studies and unknown irritancy/comedogenicity currently limit its confident recommendation for precision skincare formulations.
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