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CITRONELLYL NITRILE.

Questionable CAS 51566-62-2 / PERFUMING

A synthetic aromatic nitrile that provides a powerful metallic-citrus scent profile with significantly higher chemical stability than its aldehyde counterparts. In precision skincare, it is utilized as a fragrance component to ensure olfactory consistency in formulations that might otherwise degrade natural scents.

fragrance masking

Science

As a fragrance ingredient, Citronellyl Nitrile does not provide biological therapeutic pathways for skin health; instead, it functions by releasing volatile aromatic molecules that interface with olfactory receptors. Its chemical structure, featuring a nitrile group (-C≡N), makes it resistant to oxidation and base-catalyzed reactions.


Research

Low confidence
Effective range 0.01–0.2%
Optimal

0.05%


Transparency

Not commonly dusted
Min. effective
0.01%
Red flag below
0.1%

Because this is a fragrance component and not an active ingredient, 'dusting' is not applicable in a therapeutic sense. However, its presence at levels above 0.1% in leave-on products may increase the risk of contact sensitization.


The Formula

Solubility
Oil
Optimal pH 3 – 11
0 7 14

Stability

Exhibits exceptional stability in high-pH environments and oxidative conditions where natural citrus oils would fail. It is often used in functional products like soaps or detergents for this reason.


Safety

CIR Status
Irritant potential noted by IFRA
Max tested
0.2%
Pregnancy
Safe
Sensitization risk Moderate

Subject to IFRA Standards. Known to be a potential skin sensitizer; concentration must be strictly controlled to minimize the risk of allergic contact dermatitis.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Questionable

While chemically robust, Citronellyl Nitrile is a pure fragrance additive with no skin-health benefits and a moderate risk of sensitization for reactive skin types.


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