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CITRAL ETHYLENEGLYCOL CYCLIC ACETAL.

Valuable CAS 66408-78-4 / PERFUMING

A sophisticated sustained-release aromatic compound that provides a controlled lemon scent while functioning as a targeted odor-neutralizing agent. It is engineered to remain stable in alkaline environments, making it particularly effective for long-wear deodorizing applications.

perfuming deodorizing enzyme inhibitor

Science

This ingredient acts as a precursor to citral, undergoing gradual hydrolysis to release a refreshing lemon aroma over time. On a biochemical level, it inhibits leucine dehydrogenase (LDH), a bacterial enzyme produced by species such as Bacillus. By blocking this enzyme, it prevents the metabolic conversion of leucine into isovaleric acid, thereby suppressing the formation of pungent body odor at its source.


Research

Medium confidence
Effective range 0.1–20%
Optimal

0.5%

Key findings

  1. 01 In vivo testing at 0.1% concentration demonstrated a measurable reduction in isovaleric acid strength on the skin.
  2. 02 Formulations containing 0.1-10% weight demonstrate effective regulation of unpleasant body odors and sustained fragrance delivery.
  3. 03 Optimal aromatic and deodorizing performance is consistently observed in the 0.5-5% concentration range.

Transparency

Not commonly dusted
Min. effective
0.1%
Red flag below
0.05%

While often used as a simple fragrance component, its functional odor-suppression benefits require a minimum threshold of 0.1%. Percentages below 0.05% likely serve only as a brief olfactory masking agent rather than a functional enzyme inhibitor.


The Formula

Solubility
Oil
Optimal pH 7 – 10
0 7 14

Stability

Highly stable in alkaline conditions. As an acetal, it is susceptible to rapid hydrolysis and degradation in acidic environments (pH < 7.0).

Conflicts

  • strong acids

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Low acute toxicity (LD50 > 5000 mg/kg). While its parent compound Citral is a known sensitizer, studies on related citral acetals at 4% show no irritation or sensitization in human subjects. Industry standards recommend a maximum of 5% in fragrance concentrates.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

An excellent functional fragrance for high-pH formulations that provides scientifically backed, long-lasting odor protection via enzyme inhibition.


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