Science
Mechanism of Action
The efficacy of Cistus resin extract is attributed to its high concentration of polyphenolic compounds, including labdane-type diterpenes and methylated flavonoids. These compounds function as potent antioxidants, actively neutralizing reactive oxygen species (ROS) and thereby safeguarding skin cells from oxidative stress and UV-induced damage. Its anti-inflammatory action is mediated by the significant inhibition of nitric oxide (NO) release. Furthermore, it contributes to anti-aging by inhibiting elastase activity and demonstrates antimicrobial properties, particularly against Gram-positive bacteria such as Staphylococcus aureus. The flavonoids also contribute to its natural UV-protective capabilities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Inhibited approximately 90% of nitric oxide (NO) release, demonstrating potent in vitro anti-inflammatory activity, at 5 µg/mL (flavonoid fraction).
- 02 Achieved approximately 98% inhibition of nitric oxide (NO) release, further confirming in vitro anti-inflammatory activity, at 15 µg/mL (flavonoid and absolute fractions).
- 03 Exhibited natural sun protecting activity with an in vitro SPF of 3.42–3.77, at 100 µg/mL (C. ladanifer extracts).
- 04 Demonstrated potential for skin repair and wound healing (C. ladanifer preparations).
- 05 Inhibited elastase activity by 22% (labdanum absolute) and 13% (flavonoid extract), indicating in vitro anti-aging potential, at 1 mg/mL.
- 06 Showed in vitro antimicrobial activity against Staphylococcus aureus (MIC of 1.2 mg/mL for labdanum absolute; <0.3 mg/mL for purified fractions).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The resin can be efficiently extracted using alkaline water, specifically a Na2CO3 solution at approximately pH 11. It exhibits solubility in methanol/alcohol. Certain active components, such as labdane-type diterpenes, are water-insoluble, which suggests that specialized formulation techniques, like liposome encapsulation, may be beneficial for optimizing delivery in water-based systems. Waxes can be separated from labdanum by dissolving it in warm methanol and subsequently cooling the solution to negative temperatures to induce precipitation.
Safety
Safety Profile
EWG Skin Deep rates Cistus Ladaniferus Resin with 'Low' concern across categories including cancer, allergies & immunotoxicity, developmental and reproductive toxicity, and use restrictions. The US FDA recognizes it as safe for general or specific, limited use in food. ECHA (REACH regulation) registrations for various forms of labdanum resin (raw, concrete, resinoid) report no physical, environmental, or human health hazards, supported by a complete toxicological assessment. Limited evidence of dermal toxicity or allergies has been noted by ECHA. In vitro studies have indicated that Cistus extracts do not significantly impair the growth of noncancerous human keratinocytes (HaCaT) at concentrations relevant for its beneficial effects.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Cistus Species Resin Extract is a valuable botanical ingredient offering a broad spectrum of in vitro benefits, including antioxidant, anti-inflammatory, anti-aging, and antimicrobial properties, supported by a favorable safety profile.
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References
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