Science
Mechanism of Action
It functions by blocking the CRH-R1 receptor with up to 88% efficiency, effectively interrupting the signaling chain that leads to neurogenic inflammation. Its high concentration of flavonoids like myricitrin and apigenin inhibits NF-κB activation and pro-inflammatory cytokines (IL1-β, IL6), while its tyrosinase-inhibiting properties help regulate melanin production.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 A 2022 randomized clinical trial demonstrated that a 1% concentration reduced basal microcirculation by 38% and induced microcirculation by 21% after 28 days, indicating significant anti-inflammatory activity.
- 02 In-vitro assays confirmed 30–70% tyrosinase inhibition and a natural SPF contribution between 3.42 and 3.77 at concentrations of 100 µg/mL.
Transparency
Dusting Analysis
Botanical extracts are frequently used at levels below 0.1% for 'label appeal'. For Cistus Incanus to effectively inhibit neurogenic stress receptors and reduce microcirculation, concentrations of 1% are clinically validated.
The Formula
Formulation
Stability
The aqueous extract is inherently stable within a slightly acidic range and is typically free from essential oil allergens, making it highly compatible with sensitive skin formulations.
Synergies
- Vitamin C
- Niacinamide
- Hyaluronic Acid
Safety
Safety Profile
Classified as '100 Free' by SkinSAFE from common allergens. EWG rates it as low risk for toxicity and irritation, making it suitable for even the delicate eyelid area.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptionally effective botanical for mitigating neurogenic inflammation and skin stress when formulated at clinical levels near 1%.
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References
Sources