Science
Mechanism of Action
It significantly reduces sebaceous gland size and sebum production, normalizes keratinization to prevent pore clogging, and possesses anti-inflammatory properties. This creates an unfavorable environment for C. acnes and directly induces sebaceous gland apoptosis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 0.05% topical gel effectively reduced mild to moderate acne lesions over 12 weeks, targeting comedogenesis.
- 02 0.1% cream improved overall appearance of photodamaged skin in a 36-week study.
- 03 0.05% combined with sunscreens improved fine wrinkles associated with photoaged skin over 6 months.
Transparency
Dusting Analysis
Cis-retinoic acid is a prescription ingredient not typically found in cosmetic formulations, rendering 'dusting' irrelevant for this compound in an OTC context.
The Formula
Formulation
Stability
Highly photosensitive, though topical isotretinoin shows greater stability under fluorescent light than tretinoin, retaining 60% of its form after two hours.
Conflicts
- Tetracycline (for oral use)
- Micro-dosed progesterone preparations (for oral use)
- St. John's Wort (for oral use)
- Phenytoin (for oral use)
- Systemic corticosteroids (for oral use)
- Benzoyl peroxide (when combined in topical formulations, can amplify irritation)
Safety
Safety Profile
This is a prescription medication with known teratogenic risks, strictly contraindicated during pregnancy. Common adverse effects include dry skin, irritation, peeling, and increased sunburn susceptibility.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Due to its status as a potent prescription drug with teratogenic risks and significant regulatory hurdles, cis-retinoic acid is not suitable for cosmetic formulations.
Related
Similar Ingredients
Finding similar ingredients…