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CIS-NON-2-ENAL.

Avoid CAS 60784-31-8 / PERFUMING

An unsaturated aldehyde often associated with age-related changes in body chemistry, specifically linked to the characteristic scent of aging skin. While sometimes explored in olfactory science, its role in topical applications is scrutinized due to its impact on skin cell vitality and potential for irritation.

Olfactory marker Biological byproduct

Science

The molecule functions as a potent biological stressor; it has been shown to induce programmed cell death (apoptosis) in keratinocytes. Furthermore, it actively inhibits cellular proliferation, which can lead to a measurable reduction in epidermal thickness and disruption of the skin's structural integrity.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro 3D epidermal models demonstrate reduced layer thickness and increased markers of cellular apoptosis upon exposure.

Transparency

Not commonly dusted

This ingredient is not a standard active and is rarely found in high-performance skincare due to its cytotoxic and irritant properties.


The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As an aldehyde, it is prone to oxidation and should be handled with caution in oil-based matrices.


Safety

CIR Status
Not reviewed
Sensitization risk High

Classified as a Skin Irritant 2 and Eye Irritant 2 by ECHA. It is specifically recommended against for use in fragrance or flavoring due to its hazard profile.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Avoid

Due to its ability to trigger cell death and high potential for irritation, this ingredient should be avoided in precision skincare formulations.


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