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Moumoujus

CIS-3-METHYL-5-PHENYL-2-PENTENENITRILE.

Questionable CAS 53243-59-7 / PERFUMING

This aromatic unsaturated nitrile functions primarily as a perfuming agent, imparting a warm, green-floral to spicy-phenyl aroma to cosmetic formulations. While valued for its fragrant properties, it offers no direct beneficial effects for skin health or function.

Summary

Fragrance

Science

Mechanism of Action

CIS-3-METHYL-5-PHENYL-2-PENTENENITRILE contributes an aromatic profile to cosmetic products. Its mechanism is solely related to its volatile nature, releasing a warm, green-floral to spicy-phenyl scent without interacting directly with skin biology to confer therapeutic benefits.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As a fragrance ingredient, CIS-3-METHYL-5-PHENYL-2-PENTENENITRILE is not typically 'dusted' or used at concentrations intended for a functional skin benefit. Its usage is governed by aesthetic and safety considerations rather than active efficacy thresholds.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient is compatible with alcohol-based and oil-based systems when incorporated within recommended safety concentrations. It exhibits limited water solubility, recorded at approximately 0.74 g/L (43.83 mg/L) at 25°C.

Conflicts

  • strong acids
  • oxidizers

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
0.0062%
Sensitization risk Moderate

The Research Institute for Fragrance Materials (RIFM) has assessed the safety of 3-Methyl-5-phenylpent-2-enenitrile (encompassing both cis and trans isomers), leading to established safe use standards by the International Fragrance Association (IFRA). Its primary risks are dermal sensitization and systemic toxicity. It carries a potential for skin sensitization in a small percentage of individuals, which could manifest as temporary irritation. The No Expected Sensitization Induction Level (NESIL) is quantified at 270 µg/cm2. Maximum acceptable concentrations for finished products vary significantly by application category; for instance, 0.0062% is the limit for products applied to the axillae (Category 2), 0.021% for lips (Category 1), and 0.12% for face/body applied by fingertips (Category 3). Genotoxicity studies indicate it is not genotoxic. The FDA regulates fragrance ingredients as cosmetics, with manufacturers responsible for ensuring safety.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

As a fragrance ingredient, CIS-3-METHYL-5-PHENYL-2-PENTENENITRILE provides no direct skincare benefits and poses a moderate risk of skin sensitization, making its inclusion in precision skincare formulations debatable.

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