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Moumoujus

CIS-3-HEXENYL SALICYLATE.

Questionable CAS 65405-77-8 / PERFUMING

Cis-3-Hexenyl Salicylate is an ester primarily utilized in cosmetic and personal care formulations for its distinct fresh, green-floral, and herbaceous aroma. It contributes a characteristic 'cut grass' note, acting solely as a perfuming agent within these products.

Summary

Perfuming agent Fragrance

Science

Mechanism of Action

Operating exclusively as a fragrance component, Cis-3-Hexenyl Salicylate imparts a fresh, green-floral scent profile with warm balsamic undertones. Its function is limited to aromatic contribution, with no known specific mechanism of action on the skin providing therapeutic benefits such as exfoliation or anti-inflammatory effects.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Cis-3-Hexenyl Salicylate is incorporated into formulations for its aromatic properties, not for direct skincare efficacy. Therefore, the concept of 'dusting'—overstating active benefits at insufficient concentrations—is not applicable to this ingredient.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ester is oil-soluble and immiscible with water. It can hydrolyze over time, potentially forming salicylic acid, and may also exhibit discoloration due to the presence of a benzenic cycle. It demonstrates good stability in specific applications like shampoos and soaps, moderate stability in fine fragrances, but poor stability in powder detergents and certain antiperspirant/deodorant products. Optimal storage is in a cool, well-ventilated, tightly closed container, protected from heat and light.

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
3.9611%
Pregnancy
Caution
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Cis-3-Hexenyl Salicylate is safe for cosmetic use when formulated to be non-irritating and non-sensitizing, with a maximum reported use concentration of 3.9611%. It is also Generally Recognized as Safe (GRAS) by the FDA as a food additive. However, aggregated GHS information indicates it 'May cause an allergic skin reaction'. Significantly, the Danish centre on endocrine disruptors has identified this substance as an endocrine disruptor, raising concerns about potential developmental and reproductive toxicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While commonly employed for its fresh aromatic profile at concentrations up to 3.9611%, Cis-3-Hexenyl Salicylate raises significant concerns due to its potential for allergic skin reactions and its classification as an endocrine disruptor with implications for developmental and reproductive toxicity.

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