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Moumoujus

CINNAMOMUM CAMPHORA GUM EXTRACT.

Questionable CAS 92201-50-8 / 8022-91-1 / 8008-51-3 / ASTRINGENT, SKIN CONDITIONING

Cinnamomum Camphora Gum Extract is derived from the camphor tree, historically recognized for its sensory attributes and diverse biological activities. While offering potential antioxidant, anti-inflammatory, and antimicrobial benefits, the application of this specific gum extract in precision skincare requires careful consideration due to limited direct clinical evidence and noted safety concerns.

Summary

Antioxidant Anti-inflammatory Antimicrobial Skin-soothing Anti-aging Astringent Penetration enhancer

Science

Mechanism of Action

A key active component, camphor, interacts with cutaneous nerve endings to produce localized warming or cooling sensations and a mild analgesic effect. It demonstrates antibacterial, antifungal, and antioxidant capabilities, alongside anti-inflammatory action achieved through cytokine secretion control and modulation of STAT1/ERK1/2 pathways. This extract may also contribute to reinforcing the skin's barrier, stimulating collagen and elastin synthesis for anti-aging and wound healing benefits, while additionally functioning as a penetration enhancer and an astringent.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Animal studies suggest camphor cream is effective in treating wounds and ultraviolet light-induced wrinkles by stimulating elastin and collagen production.
  2. 02 Cinnamomum camphora leaf extracts, at 100 mg/kg in mice, showed ameliorative effects on 2,4-dinitrochlorobenzene-induced atopic dermatitis.
  3. 03 In vitro, Cinnamomum camphora leaf extracts at 200 mg/mL effectively inhibited bacterial growth.

Transparency

Dusting Analysis

Not commonly dusted

There is no specific data indicating this ingredient is commonly 'dusted' with exaggerated claims in the skincare industry.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

To potentially enhance thermal stability and achieve controlled release, microencapsulation techniques using agents like gelatin/gum arabic have been explored for Cinnamomum camphora essential oil, which may offer relevant insights for formulating gum extracts.

Conflicts

  • This ingredient carries a notable risk of irritation, including redness, itching, and sensitivity, particularly in individuals with sensitive skin or when used at higher concentrations, necessitating patch testing.
  • The risk of adverse reactions is heightened when combined with other potentially irritating ingredients.
  • Related 'Camphor white essential oil' is explicitly recognized as a skin and eye irritant and a sensitizer by the EU.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

A specific CIR review for 'Cinnamomum camphora gum extract' is currently unavailable. The FDA's Substance Registration System lists 'Cinnamomum Camphora (Camphor) Gum Extract' as 'non-approved' under 'Substance Class: Concept', indicating it is not approved as an active drug ingredient. While the SCCS has not specifically reviewed the gum extract, the EU Cosmetics Regulation sets usage guidelines for related 'camphor leaf extract' due to potential adverse reactions at higher doses. Camphor itself is known to cause allergic reactions on the skin and is highly poisonous if ingested, with reported lethal oral doses in adults ranging from 50–500 mg/kg.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
No Sensitive
Irritancy Medium
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While offering potential benefits, the significant irritation and sensitization risks, alongside insufficient specific data for the gum extract, make its inclusion in precision formulations problematic.

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