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CI 47000.

Avoid CAS 8003-22-3 / COLORANT

CI 47000, also known as Quinoline Yellow or D&C Yellow No. 11, is a synthetic, oil-soluble cosmetic colorant primarily used to impart a yellow hue to various personal care formulations. While widely employed for its pigmenting properties, research indicates significant safety concerns beyond its coloring function.

Summary

Cosmetic Colorant

Science

Mechanism of Action

As a cosmetic colorant, CI 47000 functions by physically imparting a yellow color to products, skin, nails, or hair. Beyond this primary role, in vitro studies have shown that Quinoline Yellow can induce DNA damage at low concentrations, specifically ranging from 0.5 to 20 μg mL⁻¹. This interference extends to potentially disrupting DNA repair mechanisms. Furthermore, cellular assays have reported endocrine activity associated with this ingredient.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data indicates that CI 47000 is commonly 'dusted' or presents risks related to airborne particles in typical cosmetic applications.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For its oil-soluble forms (D&C Yellow No. 11 / Solvent Yellow 33), CI 47000 should be integrated into the oil phase of a formulation. It demonstrates heat tolerance, but stable storage necessitates protection from direct sunlight and moisture to maintain integrity.

Conflicts

  • Oxidizing agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

CI 47000 (D&C Yellow No. 11) is permitted by the FDA for external use in drugs and cosmetics, requiring certification, but has been delisted for ingested applications. In the European Union, it is regulated under EC Cosmetics Regulation No. 1223/2009 as a colorant, with specific maximum concentrations and restricted application areas detailed in Annex IV. Notably, its use is prohibited in products applied to or near mucous membranes, such as the lip and eye areas. Significant safety concerns include evidence of carcinogenicity from animal studies, potential developmental effects, endocrine disruption, and in vitro genotoxicity, including interference with DNA repair. High doses in animal testing have also been linked to kidney and liver effects. This ingredient has the potential to induce allergic skin reactions and is recognized as an irritant to the eyes, respiratory system, and skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite its function as a cosmetic colorant, CI 47000 presents a range of serious safety concerns, including genotoxicity, endocrine disruption, and irritation potential, rendering it unsuitable for precision skincare formulations.

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