Science
Mechanism of Action
This ingredient functions exclusively as a cosmetic colorant, providing aesthetic appeal rather than direct dermatological benefits. Its deep red pigment is a result of its chemical structure as a synthetic xanthene dye. The observed color shift, from colorless to pink under specific low pH and moisture conditions, is an inherent characteristic of its molecular properties.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
CI 45380 is heat tolerant and maintains stability within a pH range of 4.0 to 7.0. However, some variants may exhibit stability up to pH 11. Its color is highly pH-dependent, appearing colorless when dry but transforming to pink at very low pH levels, specifically between 0.0 and approximately 3.0.
Safety
Safety Profile
CI 45380 is permanently listed and requires certification by the FDA for use in drugs and cosmetics. It is approved for external cosmetic applications and general cosmetics, including lipsticks, but usage is strictly restricted from areas around the eyes. Application amounts must adhere to current good manufacturing practices and FDA allowable quantities. While generally considered safe within regulated concentrations, its high color intensity necessitates use in very small quantities. Although EWG notes low concerns for irritation and allergies, individuals with sensitive skin should conduct patch testing due to the potential for irritation or allergic reactions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
CI 45380 is an optional synthetic colorant, providing a deep red hue for cosmetic formulations, with generally low irritation and comedogenicity risks.
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