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CHOLESTERYL LANOLATE.

Valuable CAS 223706-99-8 / SKIN CONDITIONING

A biomimetic skin conditioning agent, Cholesteryl Lanolate is an ester derived from lanolin, designed to closely resemble the natural lipids found in the skin's outermost layer. It functions to support and maintain a healthy skin barrier, effectively locking in moisture.

Skin conditioning agent Emollient Barrier repair Barrier maintenance Moisturizer Reduces Transepidermal Water Loss (TEWL) Softens skin Moisture retention

Science

Cholesteryl Lanolate acts as an emollient by integrating with the skin's lipid matrix. Its biomimetic structure allows it to mimic the function of natural skin lipids, thereby strengthening the skin barrier, reducing transepidermal water loss (TEWL), and imparting a softer texture while retaining essential hydration.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

As a lipophilic cholesteryl ester, Cholesteryl Lanolate is insoluble in water but soluble in various organic solvents and vegetable oils. While a specific optimal pH range for its stability is not explicitly available, cholesterol-containing liposomes demonstrate enhanced stability with increased cholesterol content and reduced acid sensitivity.


Safety

CIR Status
Safe as used
Max tested
40%
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Cholesteryl Lanolate, along with related Lanolin materials, is safe for topical application at current usage concentrations. Maximum reported use concentration is 40% in leave-on products and 10% in rinse-off products as of 2022. No specific SCCS opinion was identified.


Your Skin

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Valuable

Cholesteryl Lanolate is a valuable biomimetic emollient, effectively supporting the skin's natural barrier function and enhancing moisture retention for dry, sensitive, and normal skin types, with established safety for topical use.


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