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Moumoujus

CHOLESTERYL GLUCOSIDE.

Valuable / SKIN CONDITIONING

Cholesteryl Glucoside is a cholesterol derivative integral to maintaining the skin's natural barrier function. It acts as a moisturizing agent and helps regulate skin permeability, thereby contributing to overall skin resilience.

Summary

Skin conditioning Emollient Emulsifying Stabilizing Viscosity controlling Barrier reinforcement Moisturizing Permeability regulation Absorption enhancer

Science

Mechanism of Action

This ingredient functions as glucosylated cholesterol (GlcChol) within the stratum corneum, where it is naturally synthesized from glucosylceramide and cholesterol via β-glucosidase enzymes. As a key component of the skin's lipid barrier, Cholesteryl Glucoside aids in reinforcing barrier integrity, enhancing hydration, and modulating transepidermal water loss. Its presence can also facilitate the absorption of other active ingredients into the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Activated heat shock transcription factor 1 (Hsf1) in TIG-3 human fetal lung fibroblasts, leading to increased expression of heat shock protein 70 (Hsp70).
  2. 02 Prevented ulcer formation following cold-restraint stress and increased Hsf1 activity and Hsp70 expression and protein levels in rat gastric mucosa.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Cholesterol derivatives, including Cholesteryl Glucoside, can function as emulsion stabilizers and promote the formation of lamellar structures, positively influencing the texture and stability of cosmetic emulsions.

Synergies

  • Improved absorption of other active ingredients.

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Low

The CIR Expert Panel assessed the safety of alkyl glucosides (a broader class including Cholesteryl Glucoside) and concluded they are safe in current practices of use and concentration when formulated to be non-irritating. Human skin contains glucoside hydrolases, which are expected to metabolize these ingredients into fatty acids and glucose. While no specific maximum concentration for Cholesteryl Glucoside was defined, Lauryl Glucoside (another alkyl glucoside) was noted to be safe up to 5% a.i. in leave-on formulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Cholesteryl Glucoside is a valuable cholesterol derivative that significantly supports the skin barrier, enhances moisturization, and offers beneficial formulation properties, making it suitable for a wide range of skin types.

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