Science
Mechanism of Action
It functions as a sulfhydryl alkylating reagent, forming covalent bonds with cysteine's thiol groups. This mechanism prevents protein disulfide bond formation, contributing to its broad-spectrum antimicrobial activity.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient reacts with strong bases, such as sodium hydroxide, to produce glycolic acid derivatives, indicating instability in alkaline environments. Its own pH in water is 3.8-4.1.
Conflicts
- Strong bases (e.g., NaOH)
Safety
Safety Profile
The CIR Expert Panel concluded chloroacetamide is unsafe due to its potent human sensitizer potential. It is also classified as very toxic, with suspicions of reproductive toxicity and teratogenicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Chloroacetamide is deemed unsafe for cosmetic use due to its high sensitizing potential, irritancy, and toxicity, warranting its complete avoidance in skincare formulations.
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