Science
Mechanism of Action
This compound disrupts bacterial cell walls and membranes. At lower concentrations (0.02%-0.06%), it induces membrane leakage; at higher concentrations (>0.1%), it forms irreversible intracellular precipitates leading to cell death.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated promising antimicrobial efficacy in personal care products, with results comparable to triclosan.
- 02 Preliminary human studies indicate its efficacy and safety when used in dentifrice formulations.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stable within a near-neutral pH range of 5.0-7.0, with activity diminishing at lower pH values. The general chlorhexidine compound is a strong base.
Conflicts
- Anionic compounds (e.g., soaps, detergents, some polymers) can reduce antibacterial activity due to charge neutralization.
- Certain alcohols may diminish antibacterial effects in some formulations.
- Anionic components of toothpaste (e.g., sodium lauryl sulfate) can interact, forming low solubility salts.
Safety
Safety Profile
The CIR Expert Panel concluded Chlorhexidine and its salts are safe within specified concentration limits (e.g., up to 0.20% for Digluconate), though no specific SCCS opinion for Diundecylenate was found. While this form has demonstrated safety, the FDA has warned of rare but serious allergic reactions with chlorhexidine gluconate, advising label warnings.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Chlorhexidine Diundecylenate is a valuable broad-spectrum antimicrobial agent, demonstrating safety and efficacy in preliminary studies for personal and oral care applications.
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References
Sources